ICPMS Analysis of Complex Sample Matrices: Challenges and Considerations

Inductively coupled plasma mass spectrometry (ICP-MS) is widely used for analysis of environmental samples via methods EPA methods 6020 and 200.8. Although the instrumentation has evolved substantially from the first introduction of these methods, there are still samples types that can pose unique challenges during analysis. Most of the challenges occur during the analysis of samples with high non-target metals, minerals, or anions through polyatomic interferences or through interface issues associated with high dissolved solids. The end results can be false positive data or high reporting limits due to required dilutions, both of which pose serious limitations to low-level analysis of metals in environmental samples.

Newer technology now exists to help all of these issues through elimination of the polyatomic interferences or removing the matrix. Modern instruments are equipped with triple quadrupole technology, which has the ability to eliminate polyatomic interferences thus eliminating the need for dilutions and allowing these methods to see much lower concentrations. In addition, techniques such as EPA method 1640 are also available to remove the sample matrix (e.g interfering high minerals, anions, and dissolved solids) while retaining the ability to analyze target elements at low concentrations.

Original Airdate:  Tuesday, July 11, 2023
 
Length:  60 minutes 

Presenter: Patrick Garcia-Strickland & Kyle Groden - Eurofins Environment Testing