MALDI-TOF MS Successful for Protein Characterization
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Biochemists at Lancaster Laboratories are successfully characterizing proteins, complex carbohydrates and nucleic acids by developing and validating new methods for determining molecular weights using matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS). The Applied Biosystems Voyager DE PRO Workstation in use at Lancaster Laboratories features vacuum MALDI as its method of ionization, a technique that offers improved sensitivity over atmospheric pressure (AP) MALDI. Other benefits of the technology include:
- Ability to analyze small sample size
- Speed of analysis
- No upper mass limit
- Lack of protein de-convolution
- Decreased opportunity for bias in test results
Dr. Robert J. Duff, manager of the Biochemistry Group at Lancaster Laboratories oversees the analysis. “Sample preparation for MALDI-TOF MS analysis can be challenging, so experienced, Ph.D. level biochemists are performing the tests and operating our instrument,” says Dr. Duff. For more information about MALDI-TOF MS analysis, contact Pharmaceutical Business Development at 717-656-2300.