Chondroitin Testing Package

Chondroitin sulfate belongs to a group of complex polysaccharides known as glycosaminoglycans (GAGs) or mucopolysaccharides. GAGs are present in the tissue of vertebrate animals (e.g., bovine trachea) and have mainly a linear structure with a repeating unit containing D-glucuronic acid and N-acetylgalactosamine. The N-acetylgalactosamine is either sulfated in the C-4 position (chondroitin sulfate A) or the C-6 position (chondroitin sulfate C). Chondroitin sulfate, in conjunction with glucosamine and MSM, is used as a dietary supplement to slow the progression of osteoarthritis.

Due to the complexity of chondroitin sulfate, many different analytical techniques are used for its characterization and determination of purity.

The CPC titration cannot differentiate between chondroitin sulfate and other GAGs or large molecular anions, such as carrageenan, proteins, and surfactants. Using CPC alone does not ensure the quality of your product. A combined testing package of CPC and enzymatic HPLC will assure identity and confirm the purity of materials. Enzymatic HPLC is highly specific and not subject to positive interferences. Raw material analyses are reported on the dry weight basis (following moisture determination) in accordance with the USP monograph.

To determine purity and identification of chondrotin sulfate Eurofins is offering the following packaged tests:

• CPC titration for the content of chondroitin sulfate (total glycosaminoglycans)

• Enzymatic HPLC (AOAC) for content and identification

• Loss on Drying (USP) (raw materials only)

By offering batched analyses Eurofins can offer competitive pricing while ensuring purity and identity of chondroitin raw materials. Methods can be applied to most dietary supplement matrices. To obtain additional information and pricing, please contact us here.